interface graph thumbnail
legend  pdf

structure nameSTRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
(DNA topoisomerase I)
referenceChrencik et al. J.Mol.Biol. 339 773 2004
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=0.292)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureERKYMKNKN

Estimated binding specificities ?

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# IC=4.475 IC/col=0.895 n_of_columns=5 specificity:   
A |  96  16   0   0  13
C |   0  54   0   0  13
G |   0  13   0   0  57
T |   0  13  96  96  13
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updated Mon Dec 18 05:57:50 2023