| structure name | STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I (DNA topoisomerase I) |
| reference | Chrencik et al. J.Mol.Biol. 339 773 2004 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.30, R-factor=0.278) |
| structural superfamily | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain; |
| sequence family | Eukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti; |
| reference complex | 1a31_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | ERKYMKNKF |
Estimated binding specificities ?
| readout + contact |  |
A | 64 0 53 0 11 24 24 24 24 24 96 C | 21 11 10 0 0 24 24 24 24 24 0 G | 11 0 12 0 85 24 24 24 24 24 0 T | 0 85 21 96 0 24 24 24 24 24 0scan! |
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updated Thu Sep 12 15:26:13 2024