| structure name | STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I (DNA topoisomerase I) |
| reference | Chrencik et al. J.Mol.Biol. 339 773 2004 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.30, R-factor=0.278) |
| structural superfamily | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain; |
| sequence family | Eukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti; |
| reference complex | 1a31_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | ERKYMKNKF |
Estimated binding specificities ?
| readout + contact |  |
A | 0 24 24 24 24 24 0 69 26 96 8 C | 0 24 24 24 24 24 96 2 8 0 8 G | 0 24 24 24 24 24 0 8 10 0 19 T | 96 24 24 24 24 24 0 17 52 0 61scan! |
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updated Sat Aug 2 01:48:19 2025