1rrj_A : 3D-footprint complex

structure name	STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I (DNA topoisomerase I)
reference	Chrencik et al. J.Mol.Biol. 339 773 2004
source	Homo sapiens
experiment	X-ray (resolution=2.30, R-factor=0.278)
structural superfamily	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence family	Eukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex	1a31_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1rrj_A interface=156,164,225,226,228,236,291,332,440, qkwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatffakmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqmskeeklkikeenekllkeygfcimdnhkerianfkiEppglfrgRgnhpkmgmlkrrimpediiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsiKYiMlnpssriKgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalragNekeegetadtvgccslrvehinlhpeldgqeyvvefdflgKdsiryynkvpvekrvfknlqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapdenipakilsynranravailcnhqrappktFeksmmnlqtkidakkeqladarrdlksakadakvmkdaktkkvveskkkavqrleeqlmklevqatdreenkqialgtsklsldpritvawckkwgvpiekiynktqrekfawaidmadedyef
interface signature	ERKYMKNKF

Estimated binding specificities ?

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# IC=5.493 IC/col=0.499 n_of_columns=11

specificity:

A |  64   1  64   0  10  24  24  24  24  24  96
C |  12  10  22   0   0  24  24  24  24  24   0
G |  10   0  10   0  85  24  24  24  24  24   0
T |  10  85   0  96   1  24  24  24  24  24   0

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updated Thu Jan 8 19:04:05 2026