1t2k_ABCD : 3D-footprint complex

structure name	STRUCTURE OF THE DNA BINDING DOMAINS OF IRF3, ATF-2 AND JUN BOUND TO DNA
reference	Harrison et al. 'Embo 23 4384 2004
source	HOMO SAPIENS
experiment	X-ray (resolution=3.00, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	2pi0_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1t2k_A interface=40,76,77,79,80,84, tpkprilpwlvsqldlgqlegvawvnksrtrfripwkhgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalnRkeglrlaedrskdphdphkiyefvns > 1t2k_B interface=37,39,75,76,78,79,80,83, pkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSAlnRkeglrlaedrskdphdphkiyefvn > 1t2k_C interface=10,11,14,17,18, mkaerkrmrNRiaAskSRkrkleriarleekvktlkaqnselastanmlreqvaqlkqkvmn > 1t2k_D interface=9,10,12,13,16,17, krrkflerNRaAAsrSRqkrkvwvqslekkaedlsslngqlqsevtllrnevaqlkqllla
interface signature	LRNRSR/HLRNRSAR/NRASR/NRAASR

Estimated binding specificities ?

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# IC=15.684 IC/col=0.784 n_of_columns=20

specificity:

A |   1   0   9  80  69  24   7   0   9  24   9  24  24  71   0   0   0   0  96  96
C |   3   0  11  14   9  24   4   0  11  24  67  24  24   7   0   0   0  96   0   0
G |   8   0   7   1   9  24   7   0   0  24  11  24  24   7   0  96   0   0   0   0
T |  84  96  69   1   9  24  78  96  76  24   9  24  24  11  96   0  96   0   0   0

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updated Sun Jan 4 23:39:36 2026