2pi0_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER (Interferon regulatory factor 3)
reference	Nistal-Villan et al. Mol.Cell 26 703 2007
source	Homo sapiens
experiment	X-ray (resolution=2.31, R-factor=0.185)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	1t2k_ABCD 2o61_AB 2pi0_ABCD
redundant complexes	1t2k_A 2o61_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2pi0_B interface=40,42,78,79,81,82,85,86, mgtpkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalNRkeglrlaedrskdphdphkiyefvns
interface signature	HLRNRSNR

Estimated binding specificities ?

readout + contact

# IC=2.714 IC/col=0.678 n_of_columns=4

specificity:

A |   9   0   9  11
C |   9   0   9  67
G |   9   0   9   9
T |  69  96  69   9

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: IRF-3
AANNGAAA	PubMed	2pi0_B(1.87e-03), 2o6g_EFGH(6.46e-04), 2pi0_ABCD(6.19e-04)

Dendrogram of similar interfaces ?

matrix format

  
  HTLT--------RGNT--RGSTAT--RA--   L           +-----------------------------2o6g_G    
                                             +-1 
  ----------NAST----RTHT--STLT--   L       +-2 +-----------------------------4lg0_A    
                                           ! ! 
  ----ECKT----RGAT--------------   L     +-3 +-----------------------------1pue_E    
                                         ! ! 
  ------DCKT----RG----RGYA----KA   L   +-4 +-----------------------------5jvt_A    
                                       ! ! 
  ------QCKT----RGAT--RGNT------   L --5 +-----------------------------8smh_F    
                                       ! 
  ------DCKT----RGST--RGYA------   L   +-----------------------------4bnc_A

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updated Mon Jun 29 15:31:38 2026