2pi0_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER (Interferon regulatory factor 3)
reference	Nistal-Villan et al. Mol.Cell 26 703 2007
source	Homo sapiens
experiment	X-ray (resolution=2.31, R-factor=0.185)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	1t2k_ABCD 2o61_AB 2pi0_ABCD
redundant complexes	1t2k_A 2o61
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2pi0_B interface=40,42,78,79,81,82,85,86, mgtpkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalNRkeglrlaedrskdphdphkiyefvns
interface signature	HLRNRSNR

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5

specificity:

A |   0  96  96  54  13
C |   0   0   0  13  13
G |  96   0   0  13  54
T |   0   0   0  16  16

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: IRF-3
AANNGAAA	PubMed	2pi0_B(1.87e-03), 2o6g_EFGH(6.46e-04), 2pi0_ABCD(6.19e-04)

Dendrogram of similar interfaces ?

matrix format

  
  HTLT------RGNT--RGSTAT--RA--   L       +-----------------------------2o6g_G    
                                       +-2 
  --------NAST----RTHT--STLT--   L     ! +-----------------------------4lg0_A    
                                     +-3 
  ----DCKT----RG----RGYA----KA   L   ! !                            +5jvt_A    
                                   --4 +----------------------------1 
  ----DCKT----RGST--RGYA------   L   !                              +4bnc_A    
                                     ! 
  ----QCKT----RGAT--RGNT------   L   +-----------------------------8smh_F

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updated Sat Jan 10 05:30:09 2026