interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER
(Interferon regulatory factor 3)
referenceNistal-Villan et al. Mol.Cell 26 703 2007
sourceHomo sapiens
experimentX-ray (resolution=2.31, R-factor=0.185)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes1t2k_ABCD 2o6g_EFGH 2pi0_ABCD
redundant complexes1t2k_A 2o6g_H
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHLRNRSNR

Estimated binding specificities ?

readout + contactlogo
# IC=2.917 IC/col=0.729 n_of_columns=4 specificity:   
A |  12   0  12   0
C |  12   0  12  84
G |  12   0  12   0
T |  60  96  60  12
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: IRF-3
AANNGAAAPubMed2pi0_B(1.87e-03), 2o6g_EFGH(6.46e-04), 2pi0_ABCD(6.19e-04)

Dendrogram of similar interfaces ?

matrix format
  
  ECKT----RGAT--RGHT----RA--   L                                  +---4mhg_A    
                                                                +-1 
  --KT----RG----RGYT--------   L       +------------------------2 +---4bqa_A    
                                       !                        ! 
  --KT----RG----RGYA--------   L     +-3                        +----4l18_B    
                                     ! ! 
  ------NAST--RGHT--ST------   L   +-4 +-----------------------------2uzk_A    
                                   ! ! 
  ----NAST----RTHT--ST------   L --5 +-----------------------------3l2c_A    
                                   ! 
  ----NAST----RGHT--STLT--KA   L   +-----------------------------2c6y_A    
                                 

home
updated Fri Sep 13 16:35:59 2024