1u8r_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AN IDER-DNA COMPLEX REVEALS A CONFORMATIONAL CHANGE IN ACTIVATED IDER FOR BASE-SPECIFIC INTERACTIONS
reference	Wisedchaisri et al. J.Mol.Biol. 342 1155 2004
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.75, R-factor=?)
structural superfamily	Iron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;C-terminal domain of transcriptional repressors;
reference complex	1u8r_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1u8r_A interface=37,39,40,43,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsQtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipgldelgvglvrltelpagspvavvvrqltehvqgdidlitrlkdagvvpnarvtvettpgggvtivipghenvtlphemahavkvekv > 1u8r_B interface=37,39,40,42,43,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSQtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipgldelgvglvrltelpagspvavvvrqltehvqgdidlitrlkdagvvpnarvtvettpgggvtivipghenvtlphemahavkvekv > 1u8r_C interface=37,39,40,43,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsQtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipgldelgvglvrltelpagspvavvvrqltehvqgdidlitrlkdagvvpnarvtvettpgggvtivipghenvtlphemahavkvekv > 1u8r_D interface=37,39,40,43,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsQtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipgldelgvglvrltelpagspvavvvrqltehvqgdidlitrlkdagvvpnarvtvettpgggvtivipghenvtlphemahavkvekv
interface signature	SPTQR/SPTSQR/SPTQR/SPTQR

Estimated binding specificities ?

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# IC=17.701 IC/col=1.041 n_of_columns=17

specificity:

A |   2   5  96  10   0   0   5  96   0   0   0   0  12   0   7   5   0
C |   2   8   0   6   0   0  74   0   0  96  96   0  12   0   6  75   0
G |   4  10   0  75  96  96  10   0  96   0   0   0  60   0  78   6   0
T |  88  73   0   5   0   0   7   0   0   0   0  96  12  96   5  10  96

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updated Tue Jul 29 16:58:11 2025