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structure nameHHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2- AMINOPURINE OPPOSITE TO THE TARGET BASE (GCGC:GMPC) AND SAH
(MODIFICATION METHYLASE HHAI)
referenceKlimasauskas et al. 'Nucleic 33 6953 2005
sourceHAEMOPHILUS HAEMOLYTICUS
experimentX-ray (resolution=1.70, R-factor=0.196)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase;
redundant complexes2z6u 2uyc 2z6a 9mht 2uz4 2c7o 2uyh 2z6q 2hr1 4mht 1skm 6mht 1fjx 2i9k 2c7q 2c7r 1m0e 3mht 10mh 3eeo 5mht 7mht 2zcj 1mht 8mht
reference complex5ciy_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureCISENVRRRQRSYAKN

Estimated binding specificities ?

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# IC=4.632 IC/col=0.926 n_of_columns=5 specificity:   
A |  20  74   0   0   0
C |  38   7   0  96   0
G |  19   7  96   0  96
T |  19   8   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------CC----ITSG------ECNCVCRCRCRA----QG--RGSGYC--ATKT--NC   L                          +----2c7p_A    
                                                                              +-------------------1 
  --------------------VGQG------------------FGNGSGEG------AGNG--RA--   L   +--2                   +----4dkj_A    
                                                                           !  ! 
  ----------NAFA----------------------------------------------------     --3  +------------------------2y7h_B    
                                                                           ! 
  FTDTITVTYTAT----KAAA----WGLGIT------------------------------------   L   +---------------------------3zh2_C    
                                                                         

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updated Thu Sep 12 15:59:01 2024