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structure nameHHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2- AMINOPURINE OPPOSITE TO THE TARGET BASE (GCGC:GMPC) AND SAH
(MODIFICATION METHYLASE HHAI)
referenceKlimasauskas et al. 'Nucleic 33 6953 2005
sourceHAEMOPHILUS HAEMOLYTICUS
experimentX-ray (resolution=1.70, R-factor=0.196)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase;
redundant complexes2z6u 2uyc 2z6a 9mht 2uz4 2c7o 2uyh 2z6q 2hr1 4mht 1skm 6mht 1fjx 2i9k 2c7q 2c7r 1m0e 3mht 10mh 3eeo 5mht 7mht 2zcj 1mht 8mht
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureCISENVRRRQRSYAKN

Estimated binding specificities ?

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# IC=4.632 IC/col=0.926 n_of_columns=5 specificity:   
A |  20  74   0   0   0
C |  38   7   0  96   0
G |  19   7  96   0  96
T |  19   8   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------CC----ITSG------ECNCVCRCRCRA----QG--RGSGYC--ATKT--NC   L                          +----2c7p_A    
                                                                              +-------------------1 
  --------------------VGQG------------------FGNGSGEG------AGNG--RA--   L   +--2                   +----4dkj_A    
                                                                           !  ! 
  ----------NAFA----------------------------------------------------     --3  +------------------------2y7h_B    
                                                                           ! 
  FTDTITVTYTAT----KAAA----WGLGIT------------------------------------   L   +---------------------------3zh2_C    
                                                                         

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updated Mon Dec 16 19:24:30 2024