interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF ACTIVATED NOTCH, CSL AND MAML ON HES-1 PROMOTER DNA SEQUENCE
(RECOMBINING BINDING PROTEIN SUPPRESSOR OF...)
referenceBlacklow et al. 'Cell(Cambridge,Mass.)' 124 973 2006
sourceHOMO SAPIENS
experimentX-ray (resolution=3.25, R-factor=0.241)
structural superfamilyp53-like transcription factors;DNA-binding protein LAG-1 CSL;E set domains;
sequence familyBetatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes3nbn_AD
reference complex3iag_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYERSKSQ

Estimated binding specificities ?

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# IC=7.169 IC/col=0.896 n_of_columns=8 specificity:   
A |   6   0   5   5   5  96   5  81
C |   5   0  81  81  80   0  80   5
G |   5   0   5   5   6   0   6   5
T |  80  96   5   5   5   0   5   5
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updated Sat Aug 2 02:33:46 2025