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structure nameSTRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA
(DNA topoisomerase 1)
referenceVan Duyne et al. Mol.Cell 23 343 2006
sourceVariola virus
experimentX-ray (resolution=2.70, R-factor=0.193)
structural superfamilyDNA breaking-rejoining enzymes;DNA topoisomerase I domain;
sequence familyEukaryotic DNA topoisomerase I, catal; Viral DNA topoisomerase I, Nterminal;
reference complex2h7g_X
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQYYRKYKRY

Estimated binding specificities ?

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# IC=7.732 IC/col=0.773 n_of_columns=10 specificity:   
A |   8   0  24  24  72   0   0   0   0   8
C |   8   0  24  24   8  96  88  88   0   8
G |   8  96  24  24   8   0   8   0   0   8
T |  72   0  24  24   8   0   0   8  96  72
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updated Mon Dec 16 19:36:50 2024