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structure nameSTRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA
(DNA topoisomerase 1)
referenceVan Duyne et al. Mol.Cell 23 343 2006
sourceVariola virus
experimentX-ray (resolution=2.70, R-factor=0.193)
structural superfamilyDNA breaking-rejoining enzymes;DNA topoisomerase I domain;
sequence familyEukaryotic DNA topoisomerase I, catal; Viral DNA topoisomerase I, Nterminal;
reference complex2h7g_X
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQYYRKYKRY

Estimated binding specificities ?

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# IC=7.820 IC/col=0.782 n_of_columns=10 specificity:   
A |  69  96   0   0   0   8  24  24   0  69
C |   8   0   0   8   0  11  24  24  96   8
G |  11   0  96  88  96   8  24  24   0  11
T |   8   0   0   0   0  69  24  24   0   8
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updated Sun Jun 28 05:40:39 2026