interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA
(DNA topoisomerase 1)
referenceVan Duyne et al. Mol.Cell 23 343 2006
sourceVariola virus
experimentX-ray (resolution=2.70, R-factor=0.193)
structural superfamilyDNA breaking-rejoining enzymes;DNA topoisomerase I domain;
sequence familyEukaryotic DNA topoisomerase I, catal; Viral DNA topoisomerase I, Nterminal;
reference complex2h7g_X
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQYYRKYKRY

Estimated binding specificities ?

readout + contactlogo
# IC=7.820 IC/col=0.782 n_of_columns=10 specificity:   
A |   8   0  24  24  69   0   0   0   0  11
C |  11   0  24  24   8  96  88  96   0   8
G |   8  96  24  24   8   0   8   0   0   8
T |  69   0  24  24  11   0   0   0  96  69
scan!

home
updated Sat Aug 2 02:38:06 2025