2isz_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A TWO-DOMAIN IDER-DNA COMPLEX CRYSTAL FORM I
reference	Wisedchaisri et al. Biochemistry 46 436 2007
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.40, R-factor=?)
structural superfamily	Iron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;
reference complex	2isz_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2isz_A interface=37,39,40,43,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsQtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_B interface=37,39,40,42,43,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSQtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_C interface=37,39,40,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsqtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_D interface=37,39,40,42,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSqtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv
interface signature	SPTQRR/SPTSQRR/SPTRR/SPTSR

Estimated binding specificities ?

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# IC=15.310 IC/col=0.901 n_of_columns=17

specificity:

A |   1   9  94  15   0   3  24  96   0   0   0   0  13  11  24   0   4
C |   0   7   0   1   0   1  24   0   0  96  96   0   9   9  24  72   1
G |   7   5   2  80  96  92  24   0  96   0   0   0  57   9  24  13   1
T |  88  75   0   0   0   0  24   0   0   0   0  96  17  67  24  11  90

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updated Tue Jul 29 17:54:12 2025