2isz_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A TWO-DOMAIN IDER-DNA COMPLEX CRYSTAL FORM I
reference	Wisedchaisri et al. Biochemistry 46 436 2007
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.40, R-factor=?)
structural superfamily	Iron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;
reference complex	2isz_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2isz_A interface=37,39,40,43,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsQtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_B interface=37,39,40,42,43,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSQtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_C interface=37,39,40,47,60, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvsqtvsRmerdgllrvagdRhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv > 2isz_D interface=37,39,40,42,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSqtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipglvelgv
interface signature	SPTQRR/SPTSQRR/SPTRR/SPTSR

Estimated binding specificities ?

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# IC=11.866 IC/col=0.791 n_of_columns=15

specificity:

A |  84  13  24  66  24  96   0   0   0   0  24   8   0   4  12
C |   4   4  24  14  24   0   0   0  96   0  24  79  96  80   8
G |   4  75  24   8  24   0  96  96   0   0  24   4   0   0  10
T |   4   4  24   8  24   0   0   0   0  96  24   5   0  12  66

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updated Mon Jan 5 00:52:37 2026