2pi0_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER
reference	Nistal-Villan et al. Mol.Cell 26 703 2007
source	Homo sapiens
experiment	X-ray (resolution=2.31, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	2pi0_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2pi0_A interface=36,66,67,69,70,74, kprilpwlvsqldlgqlegvawvnksrtrfripwkHglrgifqawaeatgayvpgrdkpdlptwkRNfRSalnRkeglrlaedrskdphdphkiyefv > 2pi0_B interface=40,42,78,79,81,82,85,86, mgtpkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalNRkeglrlaedrskdphdphkiyefvns > 2pi0_C interface=37,39,75,76,78,79, pkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalnrkeglrlaedrskdphdphkiyefv > 2pi0_D interface=38,40,71,72,74,75,76,78,79, tpkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdagifqawaeatgayvpgrdkpdlptwkRNfRSAlNRkeglrlaedrskdphdphkiyefvn
interface signature	HRNRSR/HLRNRSNR/HLRNRS/HLRNRSANR

Estimated binding specificities ?

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# IC=24.225 IC/col=0.932 n_of_columns=26

specificity:

A |   0   3  24  92  96  92  17   3   0  96  96  96   1   0   0  65   1  90  24  24   7  24  84  96  92   1
C |   0   8  24   1   0   3  78   7   0   0   0   0   2   0   0   5   0   1  24  24   5  24   1   0   1   0
G |  96  84  24   1   0   0   1   7  96   0   0   0  26  96  96   9  95   1  24  24   3  24   7   0   0  95
T |   0   1  24   2   0   1   0  79   0   0   0   0  67   0   0  17   0   4  24  24  81  24   4   0   3   0

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updated Tue Jul 29 18:31:19 2025