2xcs_BD : 3D-footprint complex

structure name	THE 2.1A CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH GSK299423 AND DNA
reference	Eggleston et al. Nature 466 935 2010
source	STAPHYLOCOCCUS AUREUS
experiment	X-ray (resolution=2.10, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	5npk_d
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2xcs_B interface=42,44,206,266,269,354,356, kladcsskspeeceiflvegdsaggstksgrdsrtqailplRgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanernitsemresfldYamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdsSiyEamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangaSgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiqlg > 2xcs_D interface=44,205,265,355, kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavynernitsemresfldYamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdsSiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql
interface signature	RKYSESI/KYSI

Estimated binding specificities ?

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# IC=7.014 IC/col=0.501 n_of_columns=14

specificity:

A |   0   0   9  24  24  10  24  24  24   5  13  24   0   0
C |  96   0   0  24  24  17  24  24  24  48  34  24  96   0
G |   0  96   0  24  24  56  24  24  24  26   8  24   0  96
T |   0   0  87  24  24  13  24  24  24  17  41  24   0   0

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updated Mon Sep 9 16:09:42 2024