interface graph thumbnail
legend  pdf

structure name1.98A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND SINGLY NICKED DNA
(DNA GYRASE SUBUNIT A)
referenceMiles et al. Bioorg.Med.Chem.Lett. 26 2464 2016
sourceSTAPHYLOCOCCUS AUREUS (STRAIN N315) / STAPHYLOCOCCUS AUREUS (STRAIN N315)
experimentX-ray (resolution=1.98, R-factor=0.166)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
multimeric complexes5cdo_ABCD 5cdo_RSTU 5cdq_ABCD 5cdq_RSTU 5cdr_AB 5cdr_CD 5iwi_AB 5iwi_CD 5iwm_ABCD 6fqm_ABCD 6fqm_abcd 6fqv_ABCD 6fqv_RSTU 6qtk_ABCD 6qtp_ABCD 6qx1_ABCD
redundant complexes5cdq_R 5cdr_A 5iwm_C 6fqv_T 6qx1_A 5cdo 6fqm 6qtk 6qtp
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence

No structural evidence for specific binding to DNA (<4 informative columns)


Dendrogram of similar interfaces ?

matrix format
  
  ------------SA------------RG----IG------------------------                                           +--2xcr_U    
                                                                                                       ! 
  YC----------SG------------RT----IG------------------------                                   +-------3    +5iwi_C    
                                                                                               !       !  +-1 
  ------------SA------------RG----IG--QT--------------------   L                               !       +--2 +5npk_d    
                                                                                           +---4          ! 
  ----RC------AT------------------IC--------------RG--------   L                           !   !          +2xkk_C    
                                                                                         +-5   ! 
  YT----------ST--------------RA--IG------------------------                             ! !   +----------5bs8_A    
                                                                                       +-6 ! 
  --------------------------------------------------LAECDAKG                           ! ! +--------------6n1p_A    
                                                                                     +-7 ! 
  ----RC------ST------------------IA------------------------                         ! ! +----------------3ksb_B    
                                                                                   +-8 ! 
  ------------SA----------------EGIGSC----------------------                       ! ! +------------------3l4j_A    
                                                                            +------9 ! 
  ----------QAAG------------------IGAG----------------------   L            !      ! +--------------------5zen_A    
                                                                         +-10      ! 
  --DC--------------------------ECIGSG----------------------   L         !  !      +---------------------4fm9_A    
                                                                      +-11  !  
  ------QA--------------------NG----------------------------          !  !  +----------------------------7k63_U    
                                                                   +-12  !  
  --------RC------------------------------------------------       !  !  +----------------------------7cow_T    
                                                                 -13  !  
  --------------NASTRGHTSTLT--------------------------------   L   !  +----------------------------7cby_C    
                                                                   !  
  --------------------------------------TAFCAGRCFA----------   L   +----------------------------6dg0_A    
                                                                 

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updated Fri Sep 13 19:51:08 2024