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structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(I-CREI V2V3 VARIANT)
referenceChion-Sotine et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.31, R-factor=0.215)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes2xe0_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQNNSRRYTRVQT

Estimated binding specificities ?

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# IC=13.142 IC/col=1.011 n_of_columns=13 specificity:   
A |   0  61  11   7   0   0  96   0   0   0  96  11  96
C |   3   9  61  80   0  96   0   0  96  84   0  13   0
G |   1   7  11   6   0   0   0  96   0  12   0  57   0
T |  92  19  13   3  96   0   0   0   0   0   0  15   0
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Dendrogram of similar interfaces ?

matrix format



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updated Sun Aug  3 06:37:26 2025