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legend  pdf

structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(I-CREI V2V3 VARIANT)
referenceChion-Sotine et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.31, R-factor=0.215)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes2xe0_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQKRSNQSATYSVDRSKT

Estimated binding specificities ?

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# IC=10.864 IC/col=0.905 n_of_columns=12 specificity:   
A |   4  93   3   3   3   0  86   0  24  64   0  96
C |   3   0  64  86   0   0   4   0  24  16  79   0
G |   3   3  16   4   0  96   3  96  24  13  16   0
T |  86   0  13   3  93   0   3   0  24   3   1   0
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Dendrogram of similar interfaces ?

matrix format

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updated Sat Jan 10 05:39:35 2026