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legend  pdf

structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(I-CREI V2V3 VARIANT)
referenceChion-Sotine et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.31, R-factor=0.215)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes2xe0_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQKRSNQSATYSVDRSKT

Estimated binding specificities ?

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# IC=10.486 IC/col=0.874 n_of_columns=12 specificity:   
A |   0   0  18  24   0   4   0  81  16  18   1  90
C |   0  16  13  24  96   1  96   0  15   1   4   1
G |   0  80  11  24   0   1   0   0  64  76   1   1
T |  96   0  54  24   0  90   0  15   1   1  90   4
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Dendrogram of similar interfaces ?

matrix format



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updated Mon Jun 29 15:44:10 2026