3brg_C : 3D-footprint complex

structure name	CSL (RBP-JK) BOUND TO DNA (Recombining binding protein suppressor of hairless)
reference	Friedmann et al. J.Biol.Chem. 283 14781 2008
source	Mus musculus
experiment	X-ray (resolution=2.20, R-factor=0.221)
structural superfamily	DNA-binding protein LAG-1 CSL;p53-like transcription factors;E set domains;
sequence family	Betatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes	3nbn_AD
redundant complexes	2f8x
reference complex	3iag_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3brg_C interface=34,37,39,139,140,166,167, ppkrltreamrnylkergdqtvlilhakvaqksYgnEkRffcpppcvylmgsgwkkkkeqmerdgcseqesqpcafigignsdqemqqlnlegknyctaktlyisdsdkrkhfmlsvkmfygnsddigvflskrikviSKpskkklknadlciasgtkvalfnrlRSqtvstrylhveggnfhassqqwgafyihlldddetvrdgyihygqtvklvcsvtgmalprliirkvdkqtalldaddpvsqlhkcafylkdtermylclsqeriiqfqatpcpkeqnkemindgaswtiistdkaeytfyegmgpvlapvtpvpvveslqlngggdvamleltgqnftpnlrvwfgdveaetmyrcgesmlcvvpdisafregwrwvrqpvqvpvtlvrndgviystsltftytpep
interface signature	YERSKRS

Estimated binding specificities ?

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# IC=7.965 IC/col=0.996 n_of_columns=8

specificity:

A |   9   0   0   0   9   0  96  67
C |  11   0   0   0   9   0   0   9
G |   9  96   0  96  67  96   0   9
T |  67   0  96   0  11   0   0  11

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Dendrogram of similar interfaces ?

matrix format

  
  YTETRGSTKG--RTSA----------   L                           +-3brg_C    
                                   +-----------------------1 
  YTETRGSTKGKT--STQA--------   L   !                       +-3brd_A    
                                 --3 
  --------------------KT----   L   !        +----------------2ram_A    
                                   +--------2 
  ------------------QA--KARC   L            +----------------1p7h_L

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updated Thu Sep 12 16:56:10 2024