interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF A DIMER OF NOTCH TRANSCRIPTION COMPLEX TRIMERS ON HES1 DNA
(RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS)
referenceBlacklow et al. Nat.Struct.Mol.Biol. 17 1312 2010
sourceHOMO SAPIENS
experimentX-ray (resolution=3.45, R-factor=0.256)
structural superfamilyp53-like transcription factors;DNA-binding protein LAG-1 CSL;E set domains;
sequence familyBetatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes3nbn_AD
reference complex3iag_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYERSKKSQ

Estimated binding specificities ?

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# IC=5.093 IC/col=0.637 n_of_columns=8 specificity:   
A |  16   0   0  24   0  75  24   9
C |   7   0  96  24  81   7  24   7
G |   7   0   0  24   7   7  24  73
T |  66  96   0  24   8   7  24   7
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updated Thu Jan 8 22:22:51 2026