interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF A DIMER OF NOTCH TRANSCRIPTION COMPLEX TRIMERS ON HES1 DNA
(RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS)
referenceBlacklow et al. Nat.Struct.Mol.Biol. 17 1312 2010
sourceHOMO SAPIENS
experimentX-ray (resolution=3.45, R-factor=0.256)
structural superfamilyp53-like transcription factors;DNA-binding protein LAG-1 CSL;E set domains;
sequence familyBetatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes3nbn_AD
reference complex3iag_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYERSKKSQ

Estimated binding specificities ?

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# IC=5.038 IC/col=0.630 n_of_columns=8 specificity:   
A |   9   0   0  24   6  75  24   6
C |   6   0  96  24  75   6  24   6
G |  13   0   0  24   9   6  24  78
T |  68  96   0  24   6   9  24   6
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updated Sat Aug 2 04:31:51 2025