3q06_ABCD : 3D-footprint complex

structure name	AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
reference	Halazonetis et al. 'Embo 30 2167 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=?)
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3q06_A interface=182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_B interface=25,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_C interface=25,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_D interface=181,182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq
interface signature	CR/KACR/KCR/ACR

Estimated binding specificities ?

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# IC=13.202 IC/col=0.943 n_of_columns=14

specificity:

A |   0  90   0   0   3   0   5  24  24  53   0  88   2   0
C |  96   0   4   0  88  96  66   2  24  10  96   4   2   0
G |   0   4   2  96   0   0  20  68  24  20   0   2   2  96
T |   0   2  90   0   5   0   5   2  24  13   0   2  90   0

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updated Fri Dec 13 16:52:45 2024