3q06_ABCD : 3D-footprint complex

structure name	AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
reference	Halazonetis et al. 'Embo 30 2167 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3q06_A interface=182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_B interface=25,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_C interface=25,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_D interface=181,182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq
interface signature	CR/KACR/KCR/ACR

Estimated binding specificities ?

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# IC=13.021 IC/col=0.930 n_of_columns=14

specificity:

A |   0  93   7   0   2   0   4  29  24  61   0  88   4   0
C |  96   1   4   0  90  96  73   2  24   9  96   2   7   0
G |   0   0   4  96   0   0  12  63  24   9   0   2   2  96
T |   0   2  81   0   4   0   7   2  24  17   0   4  83   0

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updated Wed Jun 24 17:47:56 2026