3q06_ABCD : 3D-footprint complex

structure name	AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
reference	Halazonetis et al. 'Embo 30 2167 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3q06_A interface=182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_B interface=25,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_C interface=25,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_D interface=181,182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq
interface signature	CR/KACR/KCR/ACR

Estimated binding specificities ?

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# IC=12.937 IC/col=0.924 n_of_columns=14

specificity:

A |   0  84   2   0   2   0   6  32  24  67   0  87   2   0
C |  96   4   3   0  84  96  74   4  24  15  96   4   0   0
G |   0   4   2  96   4   0  10  58  24   8   0   2   5  96
T |   0   4  89   0   6   0   6   2  24   6   0   3  89   0

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updated Mon Sep 9 19:27:22 2024