| structure name | AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY (CELLULAR TUMOR ANTIGEN P53) |
| reference | Halazonetis et al. 'Embo 30 2167 2011 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=2.40, R-factor=0.240) |
| structural superfamily | p53-like transcription factors;p53 tetramerization domain; |
| sequence family | P53 DNAbinding domain; P53 tetramerisation motif; |
| multimeric complexes | 3q05_ABCD 3q06_ABCD 3ts8_ABCD 4mzr_ABCD |
| redundant complexes | 3q06_D 3ts8_A 4mzr_D |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | KRACR |
Estimated binding specificities ?
| contact |  |
A | 9 24 0 0 9 9 C | 69 24 0 0 9 67 G | 9 24 0 96 11 11 T | 9 24 96 0 67 9scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: P53 | ||
| AGACATGCCTAGACATGCCT | PubMed | 3q05_B(7.73e-04), 3q05_ABCD(8.21e-11), 3q06_ABCD(2.70e-09), ... (total=5) |
| GTAGCATTAGCCCAGACATCTCC | PubMed | 3q05_ABCD(5.12e-04), 3q06_ABCD(1.86e-04), 4mzr_ABCD(2.40e-06) |
| GTAGCATTAGCCCAGACATGTCC | PubMed | 3q05_B(1.03e-03), 3q05_ABCD(5.26e-06), 3q06_ABCD(2.85e-07), ... (total=4) |
| TGCCT | PubMed | 3q06_ABCD(1.24e-02), 4mzr_ABCD(1.17e-02) |
| GGGCGT | PubMed | 3q06_ABCD(3.04e-03) |
| GTAGGATTAGCCCAGACATGTCC | PubMed | 3q05_B(1.03e-03), 3q05_ABCD(5.26e-06), 3q06_ABCD(2.85e-07), ... (total=4) |
Dendrogram of similar interfaces ?
matrix format------ATCTRG +3qyn_C +-----------------------------1 KG--------RG ! +7b4n_A --3 ----RGAGCCRG L ! +------------------3exj_A +----------2 --RG--TCSC-- +------------------2x6v_A |
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updated Fri Sep 13 17:34:33 2024