interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) S217H MUTANT INTASOME IN COMPLEX WITH MAGNESIUM AND DOLUTEGRAVIR (S/GSK1349572)
(PFV INTEGRASE)
referenceCherepanov et al. Mol.Pharmacol. 80 565 2011
sourceHUMAN SPUMARETROVIRUS
experimentX-ray (resolution=2.49, R-factor=0.211)
structural superfamilyRibonuclease H-like;
sequence familyIntegrase core domain;
reference complex3oym_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIRQERSP

Estimated binding specificities ?

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# IC=1.968 IC/col=0.492 n_of_columns=4 specificity:   
A |  16   9  70   3
C |  16   9   8  85
G |  19  69   8   3
T |  45   9  10   5
scan!

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updated Thu Sep 12 18:12:16 2024