interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) N224H MUTANT INTASOME IN COMPLEX WITH MAGNESIUM AND DOLUTEGRAVIR (S/GSK1349572)
(PFV INTEGRASE)
referenceCherepanov et al. Mol.Pharmacol. 80 565 2011
sourceHUMAN SPUMARETROVIRUS
experimentX-ray (resolution=2.55, R-factor=0.209)
structural superfamilyRibonuclease H-like;
sequence familyIntegrase core domain;
reference complex3oym_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIRQERP

Estimated binding specificities ?

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# IC=1.714 IC/col=0.429 n_of_columns=4 specificity:   
A |   7   7   9  45
C |   7   8  67  16
G |  74   7  11  19
T |   8  74   9  16
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updated Thu Sep 12 18:12:25 2024