3ts8_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A MULTIDOMAIN HUMAN P53 TETRAMER BOUND TO THE NATURAL CDKN1A(P21) P53-RESPONSE ELEMENT
reference	Halazonetis et al. 'Mol 9 1493 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3ts8_A interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_B interface=27,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_C interface=27,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RACR/KRACR/KACR/RACR

Estimated binding specificities ?

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# IC=11.493 IC/col=0.821 n_of_columns=14

specificity:

A |   0  93   0   0   2  80   5  24   7  24  20  85   2   0
C |  96   1   2   0   7  12  71  24   4  24  76   2   2   0
G |   0   2   4  96  12   2  15  24  68  24   0   7   4  96
T |   0   0  90   0  75   2   5  24  17  24   0   2  88   0

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updated Tue Jul 29 23:05:12 2025