3ts8_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A MULTIDOMAIN HUMAN P53 TETRAMER BOUND TO THE NATURAL CDKN1A(P21) P53-RESPONSE ELEMENT
reference	Halazonetis et al. 'Mol 9 1493 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3ts8_A interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_B interface=27,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_C interface=27,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RACR/KRACR/KACR/RACR

Estimated binding specificities ?

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# IC=11.376 IC/col=0.813 n_of_columns=14

specificity:

A |   0  93   2   0   2  78   2  24  22  24  19  87   2   0
C |  96   1   2   0   8  16  73  24   2  24  77   2   5   0
G |   0   2   2  96  16   0  14  24  56  24   0   0   2  96
T |   0   0  90   0  70   2   7  24  16  24   0   7  87   0

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updated Wed Jun 24 18:31:22 2026