3ts8_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A MULTIDOMAIN HUMAN P53 TETRAMER BOUND TO THE NATURAL CDKN1A(P21) P53-RESPONSE ELEMENT
reference	Halazonetis et al. 'Mol 9 1493 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3ts8_A interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_B interface=27,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_C interface=27,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3ts8_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RACR/KRACR/KACR/RACR

Estimated binding specificities ?

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# IC=11.477 IC/col=0.820 n_of_columns=14

specificity:

A |   0  93   2   0   2  79   4  24  13  24  16  87   2   0
C |  96   0   2   0   7  13  71  24   0  24  79   2   5   0
G |   0   2   2  96  16   2  16  24  67  24   0   5   2  96
T |   0   1  90   0  71   2   5  24  16  24   1   2  87   0

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updated Mon Sep 9 20:04:41 2024