interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF HUMAN NOTCH1 TRANSCRIPTION COMPLEX INCLUDING CSL, RAM, ANK, AND MAML-1 ON HES-1 PROMOTER DNA SEQUENCE
(RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS)
referenceBlacklow et al. Structure 20 340 2012
sourceHOMO SAPIENS
experimentX-ray (resolution=3.85, R-factor=0.213)
structural superfamilyp53-like transcription factors;DNA-binding protein LAG-1 CSL;E set domains;
sequence familyBetatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes3nbn_AD
reference complex3iag_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYERSKSQ

Estimated binding specificities ?

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# IC=7.073 IC/col=0.884 n_of_columns=8 specificity:   
A |   4   0   4   4   4  82   4  84
C |   6   0  82  82  84   4  84   4
G |   4   0   6   6   4   4   4   4
T |  82  96   4   4   4   6   4   4
scan!

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updated Sun Jun 28 09:00:42 2026