interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF HUMAN NOTCH1 TRANSCRIPTION COMPLEX INCLUDING CSL, RAM, ANK, AND MAML-1 ON HES-1 PROMOTER DNA SEQUENCE
(RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS)
referenceBlacklow et al. Structure 20 340 2012
sourceHOMO SAPIENS
experimentX-ray (resolution=3.85, R-factor=0.213)
structural superfamilyp53-like transcription factors;DNA-binding protein LAG-1 CSL;E set domains;
sequence familyBetatrefoil; LAG1, DNA binding; IPT/TIG domain;
multimeric complexes3nbn_AD
reference complex3iag_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYERSKSQ

Estimated binding specificities ?

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# IC=7.142 IC/col=0.893 n_of_columns=8 specificity:   
A |   5   6   0   5   5   5  96  81
C |   5   5   0   5   6   5   0   5
G |   5  80   0  80  80  80   0   5
T |  81   5  96   6   5   6   0   5
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updated Thu Jan 8 23:24:57 2026