3zh2_C : 3D-footprint complex

structure name	STRUCTURE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE IN COMPLEX WITH A DNA APTAMER (L-LACTATE DEHYDROGENASE)
reference	Cheung et al. Proc.Natl.Acad.Sci.USA 110 15967 2013
source	PLASMODIUM FALCIPARUM
experiment	X-ray (resolution=2.10, R-factor=0.208)
structural superfamily	LDH C-terminal domain-like;NADP-binding Rossmann-fold domains;
sequence family	lactate/malate dehydrogenase, NAD binding do; lactate/malate dehydrogenase, alpha/beta Ct;
multimeric complexes	3zh2_AB 3zh2_CD
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3zh2_C interface=34,79,88,89,231, apkakivlvgsgmiggvmatlivqknlgdvvlfDivknmphgkaldtshtnvmaysnckvsgsntyddlagadvvivtAgftkapgkSDkewnrddllplnnkimieigghikkncpnafiivvtnpvdvmvqllhqhsgvpknkiiglggvldtsrlkyyisqklnvcprdvnahivgahgnkmvllkryitvggiplqefinnklisdaeleaifdrtvntaleivnlHaspyvapaaaiiemaesylkdlkkvlicstllegqyghsdifggtpvvlgangveqvielqlnseekakfdeaiaetkrmkala
interface signature	DASDH

Estimated binding specificities ?

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# IC=14.706 IC/col=0.735 n_of_columns=20

specificity:

A |   9   9   0   0   0   0  24   0  24  24  24  24  24   0  96   0  24   9  96   0
C |   9  11  96   0   0   0  24   0  24  24  24  24  24   0   0   0  24   9   0  96
G |  69  67   0  96  96   0  24  96  24  24  24  24  24   0   0  96  24  69   0   0
T |   9   9   0   0   0  96  24   0  24  24  24  24  24  96   0   0  24   9   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  FTDTITVT----YTAT----KAAAPGKCSCDGKGWGLG--ITHA   L                             +3zh2_C    
                                                       +-----------------------2 
  ----VTVGKTMG--ATFT----------------------IT--       +-4                       +5hru_B    
                                                     ! ! 
  --------------------------------------KT----       ! +-----------------------6erp_J    
                                                   --5 
  --------------------NT----------------------       !                        +6pa7_K    
                                                     +------------------------3 
  --------------------------------PG--------TG   L                            ! +6w8b_A    
                                                                              +-1 
  ------------------CC------------------------                                  +6kdb_D

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updated Fri Sep 13 17:59:49 2024