4a12_ABCD : 3D-footprint complex

structure name	STRUCTURE OF THE GLOBAL TRANSCRIPTION REGULATOR FAPR FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH DNA OPERATOR
reference	Buschiazzo et al. 'Plos 9 3108 2013
source	STAPHYLOCOCCUS AUREUS
experiment	X-ray (resolution=3.15, R-factor=?)
structural superfamily	Thioesterase/thiol ester dehydrase-isomerase;"Winged helix" DNA-binding domain;
reference complex	4a12_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4a12_A interface=35,36,38,39,50, klkkdkrreairqqidsnpfitdhelsdlfqvsiQTiRLdrtylnipelRkriklvaeknydqissieeqefigdliqvnpnvkaqsilditsdsvfhktgiarghvlfaqanslcvalikqptvlthessiqfiekvklndtvraearvvnqtakhyyvevksyvkhtlvfkgnfkmfydkr > 4a12_B interface=36,38,39,41,42,53, etlklkkdkrreairqqidsnpfitdhelsdlfqvSiQTiRLdrtylnipelRkriklvaeknydqissieeqefigdliqvnpnvkaqsilditsdsvfhktgiarghvlfaqanslcvalikqptvlthessiqfiekvklndtvraearvvnqtakhyyvevksyvkhtlvfkgnfkmfydkr > 4a12_C interface=36,38,39,41,42,53, etlklkkdkrreairqqidsnpfitdhelsdlfqvSiQTiRLdrtylnipelRkriklvaeknydqissieeqefigdliqvnpnvkaqsilditsdsvfhktgiarghvlfaqanslcvalikqptvlthessiqfiekvklndtvraearvvnqtakhyyvevksyvkhtlvfkgnfkmfydkr > 4a12_D interface=33,35,36,38,39,50, klkkdkrreairqqidsnpfitdhelsdlfqvSiQTiRLdrtylnipelRkriklvaeknydqissieeqefigdliqvnpnvkaqsilditsdsvfhktgiarghvlfaqanslcvalikqptvlthessiqfiekvklndtvraearvvnqtakhyyvevksyvkhtlvfkgnfkmfydkr
interface signature	QTRLR/SQTRLR/SQTRLR/SQTRLR

Estimated binding specificities ?

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# IC=20.932 IC/col=0.775 n_of_columns=27

specificity:

A |  96   7  24  24  86   0   0  87  24   1  24   0   0  96  55  24  24  24   3   0  88   1   3  24  96   0  96
C |   0   1  24  24   6  71   0   1  24   5  24   0   0   0   0  24  24  24  84   0   3   3   1  24   0   0   0
G |   0   8  24  24   3  12   0   7  24   1  24   0   0   0  40  24  24  24   3   0   5  88   1  24   0   0   0
T |   0  80  24  24   1  13  96   1  24  89  24  96  96   0   1  24  24  24   6  96   0   4  91  24   0  96   0

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updated Wed Jun 24 20:02:25 2026