interface graph thumbnail
legend  pdf

structure nameNOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
referenceRittenhouse et al.
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamilyType II DNA topoisomerase;
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYSI/KYSSRRI

Estimated binding specificities ?

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# IC=8.477 IC/col=0.605 n_of_columns=14 specificity:   
A |   0   0  24  85  10  24  24  58  24  76   6  24   0   0
C |  96   0  24   0   5  24  24  17  24   5  80  24   0  96
G |   0  96  24   6  71  24  24  16  24  10   5  24  96   0
T |   0   0  24   5  10  24  24   5  24   5   5  24   0   0
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updated Mon Sep 9 21:36:04 2024