4g0u_B : 3D-footprint complex

structure name	HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMSACRINE (DNA topoisomerase 2-beta)
reference	Chan et al. 'Nucleic 41 10630 2013
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=0.159)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A;
multimeric complexes	4g0u_AB 4g0v_AB 4g0w_AB
reference complex	3qx3_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4g0u_B interface=51,53,217,220,221,269,270,311,361,363,368,370, gipklddandaggkhslectliltegdsakslavsglgvigrdrygvfplRgKilnvreashkqimenaeinniikivglqykksyddaeslktlrygkimimtdqdqdgshikgllinfihhnwpsllkhgfleefitakeakeyfadmerhrilfryagpeddaaitlafskkkiddrkewltnfmedrrqrrltkhltyndfinkelilfsnsDneRSipslvdgfkpgqrkvlftcfkrndkrevkvaqlagsvaemsayhhgeQAlmmtivnlaqnfvgsnninllqpigqfgtrlhggkdaaspRyiftmlstlarllfpavddnllkflyddnqrvepewyipiipmvlingaEgIgtgwAcKlpnydareivnnvrrmldgldphpmlpnyknfkgtiqelgqnqyavsgeifvvdrntveitelpvrtwtqvykeqvlepmlngtdktpalisdykeyhtdttvkfvvkmteeklaqaeaaglhkvfklqttltcnsmvlfdhmgclkkyetvqdilkeffdlrlsyyglrkewlvgmlgaestklnnqarfilekiqgkitienrskkdliqmlvqrgyesdpvkawkeaqgpdfnyilnmslwsltkekveelikqrdakgrevndlkrkspsdlwkedlaafveeldkvesqered
interface signature	RKDRSQAREIAK

Estimated binding specificities ?

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# IC=8.718 IC/col=0.623 n_of_columns=14

specificity:

A |   0   0   0  17  24  14  24   9  96  24  24  24   0   0
C |  96   0   0  14  24   7  24  51   0  24  24  24  96   0
G |   0  96   0  51  24  14  24  14   0  24  24  24   0  96
T |   0   0  96  14  24  61  24  22   0  24  24  24   0   0

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updated Mon Dec 18 10:23:50 2023