| structure name | HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE (DNA topoisomerase 2-beta) |
| reference | Chiang et al. Science 333 459 2011 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.16, R-factor=0.170) |
| structural superfamily | Type II DNA topoisomerase; |
| sequence family | DNA gyrase/topoisomerase IV, subunit A; |
| multimeric complexes | 4g0u_AB 4g0v_AB 4g0w_AB |
| redundant complexes | 4g0u_B
4g0v_B
 4g0w_A
4j3n_A
5gwi_B
5gwj_B
5zad_A
5zen_A
5zqf_A
5zrf_A
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Dendrogram of similar interfaces ?
matrix format--KG--------------AG--------------RT--ECIGAG---------------------------------------------- +3qx3_B +-----------------5 --KA------DC--------------------------ECIGSG---------------------------------------------- L +--10 +4fm9_A ! ! --KT--KAYA------SGAA--------------------IC----------------------------RA------------------ L ! +------------------6waa_D ! --KT--------------SA------------------EGIGSC---------------------------------------------- +-12 +-----3l4j_A ! ! +---------6 --KT--------RC----AT--------------------IC----------------------------RG------------------ L ! ! ! +-----2xkk_C ! ! ! RCKT--------------SA--------------RG----IG--QT-------------------------------------------- L ! +------9 +5npk_d ! ! +-----4 --KA--------------SA--------------RG----IG------------------------------------------------ ! ! ! +2xcr_U +-13 +--------7 --------YC--------SG--------------RT----IG------------------------------------------------ ! ! ! +5iwi_C ! ! +------1 --------YT--------ST----------------RA--IG------------------------------------------------ ! ! +5bs8_A ! ! --KT----YC--------SA--------------RG----IC------------------------------------------------ L ! ! +-------4z4q_B +-14 ! +----------8 ----------------------------------------IA------------------------------------------------ ! ! ! ! +-------4z2c_B ! ! +-----11 ------------RC--STSA--------------RG----IC------------------------------------------------ ! ! ! +3k9f_B +-15 ! +------------------3 ----------------------------------------IG------------------------------------------------ ! ! ! +6rku_A ! ! ! --KG-------------------------------------------------------------------------------------- +-16 ! +--------------------------5iwi_D ! ! ! --KT-------------------------------------------------------------------------------------- ! ! +---------------------------5bs8_D +-17 ! --KT-------------------------------------------------------------------------------------- ! ! +----------------------------4z2c_D +-18 ! --KT-------------------------------------------------------------------------------------- ! ! +----------------------------3k9f_C +-19 ! ----------------------------------------------TAFCAG--RC---------------------------------- L ! ! +----------------------------6dg0_A +-20 ! --------------------NA--RGHTSTLT---------------------------------------------------------- L ! ! +----------------------------7cby_C +-21 ! --KAKC------------------------------------------------------------------------------------ ! ! +-----------------------------6rku_D +-22 ! ----------------------NA--------ST-------------------------------------------------------- L ! ! +-----------------------------2a07_J +-23 ! --------------------------------------------------------------------------NC--AAAT----RT-- L ! ! +-----------------------------1a02_F ! ! ----------------------------------------------------------------------------NCTT--AT----RG L +-24 +-----------------------------2dgc_A ! ! ----------------------------------------------DGICLGWGQGKTLTKG--FG--FG-------------------- L ! ! +4y0f_A +-25 +-----------------------------2 ----------------------------------------------TAFCSG--------TGSG--VG---------------------- L ! ! +5tkz_B -26 ! --------------NTTCTA----------------RT---------------------------------------------------- L ! +-----------------------------5zux_A ! ------------------------------------------------------------------------NC--AT----CTRA---- +-----------------------------1s9k_E |
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updated Tue Dec 19 08:05:09 2023