4g0w_A : 3D-footprint complex

structure name	HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE (DNA topoisomerase 2-beta)
reference	Chan et al. 'Nucleic 41 10630 2013
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=0.168)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A;
multimeric complexes	4g0u_AB 4g0v_AB 4g0w_AB
reference complex	3qx3_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4g0w_A interface=52,54,212,215,216,264,265,306,358,363, kgipklddandaggkhslectliltegdsakslavsglgvigrdrygvfplRgKilnvreashkqimenaeinniikivglqykksyddaeslktlrygkimimtdqdqdgshikgllinfihhnwpsllkhgfleefitadmerhrilfryagpeddaaitlafskkkiddrkewltnfmedrrqrrlhglkhltyndfinkelilfsnsDneRSipslvdgfkpgqrkvlftcfkrndkrevkvaqlagsvaemsayhhgeQAlmmtivnlaqnfvgsnninllqpigqfgtrlhggkdaaspRyiftmlstlarllfpavddnllkflyddnqrvepewyipiipmvlingaegIgtgwAcklpnydareivnnvrrmldgldphpmlpnyknfkgtiqelgqnqyavsgeifvvdrntveitelpvrtwtqvykeqvlepmlngtdktpalisdykeyhtdttvkfvvkmteeklaqaeaaglhkvfklqttltcnsmvlfdhmgclkkyetvqdilkeffdlrlsyyglrkewlvgmlgaestklnnqarfilekiqgkitienrskkdliqmlvqrgyesdpvkawkeaqegpdfnyilnmslwsltkekveelikqrdakgrevndlkrkspsdlwkedlaafveeldkvesqered
interface signature	RKDRSQARIA

Estimated binding specificities ?

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# IC=9.165 IC/col=0.655 n_of_columns=14

specificity:

A |   0   0  24  24  24   8  24   0  96  24   0  16   0   0
C |  96   0  24  24  24   8  24  88   0  24  72  56  96   0
G |   0  96  24  24  24   8  24   0   0  24  16  16   0  96
T |   0   0  24  24  24  72  24   8   0  24   8   8   0   0

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updated Mon Dec 18 10:24:35 2023