4mzr_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A POLYPEPTIDE P53 MUTANT BOUND TO DNA
reference	Halazonetis et al. J.Mol.Biol. 426 936 2014
source	Homo sapiens
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4mzr_A interface=155,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_B interface=27,28,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_C interface=27,28,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RCR/KFRACR/KFCR/RACR

Estimated binding specificities ?

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# IC=12.825 IC/col=0.916 n_of_columns=14

specificity:

A |   0  78  80   0   2  11  75   0  24   2   0  94  75   0
C |  96   6   6   0   2  69   0   0  24   3  96   0   9   0
G |   0   6   6  96   2   8   0  20  24  89   0   0   6  96
T |   0   6   4   0  90   8  21  76  24   2   0   2   6   0

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updated Mon Sep 9 23:02:32 2024