4mzr_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A POLYPEPTIDE P53 MUTANT BOUND TO DNA
reference	Halazonetis et al. J.Mol.Biol. 426 936 2014
source	Homo sapiens
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4mzr_A interface=155,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_B interface=27,28,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_C interface=27,28,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RCR/KFRACR/KFCR/RACR

Estimated binding specificities ?

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# IC=12.807 IC/col=0.915 n_of_columns=14

specificity:

A |   0  84  82   0   3   9  48   0  24   3   0  96  80   0
C |  96   3   5   0   1  69   1   0  24   6  96   0   6   0
G |   0   6   6  96   6   9   1  16  24  84   0   0   7  96
T |   0   3   3   0  86   9  46  80  24   3   0   0   3   0

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updated Wed Jul 30 02:15:09 2025