4mzr_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A POLYPEPTIDE P53 MUTANT BOUND TO DNA
reference	Halazonetis et al. J.Mol.Biol. 426 936 2014
source	Homo sapiens
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4mzr_A interface=155,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_B interface=27,28,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_C interface=27,28,184,187, sssvpsqktyqgsygfrlgflhsgtaKFgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 4mzr_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RCR/KFRACR/KFCR/RACR

Estimated binding specificities ?

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# IC=14.137 IC/col=1.010 n_of_columns=14

specificity:

A |   0   4   2   0   2  10  77  18  14  90   0   2   2   0
C |  96   0   0   0  90  57  18   0  10   2  96   2   0   0
G |   0   2   1  96   0  18   1   1  62   2   0   7   0  96
T |   0  90  93   0   4  11   0  77  10   2   0  85  94   0

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updated Mon Jan 5 10:24:37 2026