4ond_AB : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	4ond_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_A interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg > 4ond_B interface=21,24,25,29, kvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg
interface signature	EKAR/EKAR

Estimated binding specificities ?

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# IC=8.756 IC/col=0.674 n_of_columns=13

specificity:

A |   6   0   6   0  78  24  24  24   0  24  48   0   0
C |   0   0  18  96   0  24  24  24   6  24  24  96  96
G |   6  96   6   0  12  24  24  24   0  24  18   0   0
T |  84   0  66   0   6  24  24  24  90  24   6   0   0

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updated Wed Jun 24 22:18:20 2026