4ond_AB : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5cbz_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_A interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg > 4ond_B interface=21,24,25,29, kvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg
interface signature	EKAR/EKAR

Estimated binding specificities ?

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# IC=8.663 IC/col=0.666 n_of_columns=13

specificity:

A |   0   0   7  24  81  24  24  24   7   0  73   0  79
C |   0   0  11  24   5  24  24  24   5   0   7  96   5
G |  96  96   5  24   5  24  24  24   5  96   5   0   7
T |   0   0  73  24   5  24  24  24  79   0  11   0   5

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updated Fri Dec 13 21:00:13 2024