4ond_A : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX (Ancestral SR2 Helix Mutant)
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=0.188)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
multimeric complexes	4ond_AB 4ond_EF 4oor_AB 4oor_EF 4ov7_AB 4ov7_EF 5cc0_AB
redundant complexes	5cc0_B 4oor_A 4ov7_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_A interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg
interface signature	EKAR

Estimated binding specificities ?

readout + contact

# IC=2.917 IC/col=0.729 n_of_columns=4

specificity:

A |   0   0  60  12
C |   0   0  12  60
G |  12  96  12  12
T |  84   0  12  12

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --EAKG--RTRTRT                           +2han_B    
                                      +----1 
  --EAKG--RTRTRT         +------------4    +4umm_E    
                         !            ! 
  --ECKG--KGRG--         !            +----3dzy_A    
                         ! 
  ----KAVA--RA--   L   +-8                 +5e69_A    
                       ! !            +----2 
  --ECKG--KGRG--   L   ! !   +--------5    +2ff0_A    
                       ! !   !        ! 
  ----KGVT--RG--       ! +---6        +----5emp_A    
                     --9     ! 
  --ECKG--RGRG--   L   !     +-------------3dzy_D    
                       ! 
  --ETKGAT--RG--   L   !                   +1lat_A    
                       !   +---------------3 
  --DGKG--RTRG--   L   +---7               +3cbb_A    
                           ! 
  CAECKG--KGRG--   L       +---------------6l6q_B

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updated Thu Dec 22 20:35:13 2022