4ond_EF : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5cbz_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_E interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl > 4ond_F interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	EKAR/EKAR

Estimated binding specificities ?

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# IC=11.028 IC/col=0.788 n_of_columns=14

specificity:

A |   0   0   1  16  96  24  24  24   0  16  96   4   4   1
C |   0   0   0  40   0  24  24  24   0  18   0  92  92   0
G |  96  96   3  22   0  24  24  24   0  40   0   0   0  25
T |   0   0  92  18   0  24  24  24  96  22   0   0   0  70

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updated Wed Jul 30 02:30:06 2025