4ond_EF : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	4ond_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_E interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl > 4ond_F interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	EKAR/EKAR

Estimated binding specificities ?

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# IC=10.570 IC/col=0.755 n_of_columns=14

specificity:

A |  72   1   1   6  20  96  24  24  24   0   7  95   0   0
C |   7   3   1   5  40   0  24  24  24   0  11   0  96  94
G |   7  92  90   5  13   0  24  24  24   0  69   1   0   1
T |  10   0   4  80  23   0  24  24  24  96   9   0   0   1

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updated Mon Jan 5 10:41:08 2026