4ond_EF : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	4ond_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_E interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl > 4ond_F interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	EKAR/EKAR

Estimated binding specificities ?

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# IC=10.768 IC/col=0.769 n_of_columns=14

specificity:

A |  76   5   2   2   2  96  24  24  24   0  10  87   0   2
C |   2   2   2   2  74   0  24  24  24   0   8   2  96  87
G |  13  87  90   2  15   0  24  24  24   0  68   5   0   5
T |   5   2   2  90   5   0  24  24  24  96  10   2   0   2

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updated Wed Jun 24 22:18:28 2026