4ond_EF : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.25, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5cbz_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4ond_E interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl > 4ond_F interface=22,25,26,30, qkvclicgdeasgchygvltcEgcKAffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	EKAR/EKAR

Estimated binding specificities ?

readout + contact

# IC=10.752 IC/col=0.768 n_of_columns=14

specificity:

A |  76   2   2   5   2  96  24  24  24   0  12  90   0   2
C |   2   2   5   2  74   0  24  24  24   0   8   2  96  87
G |  13  92  87   2  13   0  24  24  24   0  63   2   0   5
T |   5   0   2  87   7   0  24  24  24  96  13   2   0   2

scan!

home
updated Fri Dec 13 21:00:24 2024