4oor_AB : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH A STEROID RESPONSE ELEMENT
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.70, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5cbz_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4oor_A interface=26,27,31, pqkvclicgdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtlg > 4oor_B interface=24,25,29, kvclicgdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	KVR/KVR

Estimated binding specificities ?

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# IC=6.268 IC/col=0.482 n_of_columns=13

specificity:

A |  13  24  24   0  75  24  24  24   0   0  61  24   6
C |   9  24  24  96   9  24  24  24   0   0   6  24  82
G |   6  24  24   0   6  24  24  24   0  96  13  24   0
T |  68  24  24   0   6  24  24  24  96   0  16  24   8

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updated Wed Jul 30 02:30:16 2025