interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF THE HUMAN MINERALOCORTICOID RECEPTOR IN COMPLEX WITH DNA
(Mineralocorticoid receptor)
referenceOrtlund et al. 'Plos 9 e107000 2014
sourceHomo sapiens
experimentX-ray (resolution=2.39, R-factor=0.214)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes4tnt_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=3.968 IC/col=0.661 n_of_columns=6 specificity:   
A |  67   9  24  67   0  96
C |   9  11  24   9  96   0
G |  11  67  24  11   0   0
T |   9   9  24   9   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MINERALOCORTICOID STRUCTURE OF THE HUMAN MINERALOCORTICOID RECEPTOR IN COMPLEX WITH DNA mining
TGTCCTPubMed4tnt_B(8.80e-07)

Dendrogram of similar interfaces ?

matrix format
  
  --EAKG--RTRTRT                                  +4umm_E    
                                              +---1 
  --EAKG--RTRTRT                    +---------4   +2han_B    
                                    !         ! 
  --ECKG--KGRG--   L            +---6         +---2ff0_A    
                                !   ! 
  ----KGVT--RG--                !   +-------------5emp_A    
                                ! 
  ----KAVA--RA--   L   +--------8                 +5e69_A    
                       !        !         +-------3 
  --ECKG--RGRG--   L   !        !         !       +3dzy_D    
                       !        !  +------5 
  --ETKGAT--RG--   L   !        !  !      !       +1lat_A    
                     --9        +--7      +-------2 
  --DGKG--RTRG--   L   !           !              +3cbb_A    
                       !           ! 
  CAECKG--KGRG--   L   !           +--------------6l6q_B    
                       ! 
  --ECKG--KGRG--       +--------------------------3dzy_A    
                     

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updated Fri Sep 13 18:46:41 2024