4oor_EF : 3D-footprint complex

structure name	ANCESTRAL STEROID RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH A STEROID RESPONSE ELEMENT
reference	Ortlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
source	synthetic construct
experiment	X-ray (resolution=2.70, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5cbz_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4oor_E interface=26,27,31, pqkvclicgdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacrlrkclqagmtl > 4oor_F interface=25,26,30, qkvclicgdeasgchygvltcgscKVffkRaveghnylcagrndciidkirrkncpacrlrkclqagmtl
interface signature	KVR/KVR

Estimated binding specificities ?

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# IC=7.584 IC/col=0.542 n_of_columns=14

specificity:

A |   0  24  61   0  96  24  24  24   0   0   8  24  24  54
C |   0  24   8  96   0  24  24  24   0   0  17  24  24   8
G |  96  24  17   0   0  24  24  24   0  96  10  24  24  17
T |   0  24  10   0   0  24  24  24  96   0  61  24  24  17

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updated Wed Jul 30 02:30:27 2025