4pxi_ABCD : 3D-footprint complex

structure name	ELUCIDATION OF THE STRUCTURAL AND FUNCTIONAL MECHANISM OF ACTION OF THE TETR FAMILY PROTEIN, CPRB FROM S. COELICOLOR A3(2)
reference	Hussain et al. 'Nucleic 42 10122 2014
source	STREPTOMYCES COELICOLOR
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	Tetracyclin repressor-like, C-terminal domain;Homeodomain-like;
reference complex	4pxi_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4pxi_A interface=43, lraeqtratiigaaadlfdrrgyesttlseivahagvtkgalYfhfaakedlahaileiqsrtsrrlakdldgrgysslealmrltfgmarlcvqgpvlraglrlatapvrpplphpftewreiatsrlldavrqsdvhqdidvdsvahtlvcsvvgtreprrlaemwyilirgmvpvtrraryvtlaarleqe > 4pxi_B interface=38,39,43,44, lraeqtratiigaaadlfdrrgyesttlseivahagvTKgalYFhfaakedlahaileiqsrtsrrlakdldgrgysslealmrltfgmarlcvqgpvlraglrlatagvpvrpplphpftewreiatsrlldavrqsdvhqdidvdsvahtlvcsvvgtrtlepagreprrlaemwyilirgmvpvtrraryvtlaarleqet > 4pxi_C interface=2,38,39,43,44, lRaeqtratiigaaadlfdrrgyesttlseivahagvTKgalYFhfaakedlahaileiqsrtsrrlakdldgrgysslealmrltfgmarlcvqgpvlraglrlatagvvrpplphpftewreiatsrlldavrqsdvhqdidvdsvahtlvcsvvgtrvvgreprrlaemwyilirgmvpvtrraryvtlaarleqet > 4pxi_D interface=36,40, eqtratiigaaadlfdrrgyesttlseivahagvtKgalYfhfaakedlahaileiqsrtsrrlakdldysslealmrltfgmarlcvqgpvlraglrlatagvpvrlphpftewreiatsrlldavrqsdvhqdidvdsvahtlvcsvvgtrvagreprrlaemwyilirgmvpvtrraryvtlaarleqet
interface signature	Y/TKYF/RTKYF/KY

Estimated binding specificities ?

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# IC=11.729 IC/col=0.838 n_of_columns=14

specificity:

A |  96  96   8   0   0   8  24  24   8   0   0  24   0   0
C |   0   0  72   0   0   8  24  24   8   0  96  24  96   8
G |   0   0   8  88  96  72  24  24  72   0   0  24   0  88
T |   0   0   8   8   0   8  24  24   8  96   0  24   0   0

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updated Mon Jan 5 10:51:38 2026