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structure nameELUCIDATION OF THE STRUCTURAL AND FUNCTIONAL MECHANISM OF ACTION OF THE TETR FAMILY PROTEIN, CPRB FROM S. COELICOLOR A3(2)
(CPRB)
referenceHussain et al. 'Nucleic 42 10122 2014
sourceSTREPTOMYCES COELICOLOR
experimentX-ray (resolution=3.20, R-factor=0.223)
structural superfamilyTetracyclin repressor-like, C-terminal domain;Homeodomain-like;
sequence familyBacterial regulatory proteins, tetR family;
multimeric complexes4pxi_ABCD 5h58_ABCD
redundant complexes5h58_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTKYF

Estimated binding specificities ?

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# IC=3.968 IC/col=0.661 n_of_columns=6 specificity:   
A |   9   0   9  24  11   0
C |  67  96  67  24   9   0
G |   9   0  11  24   9   0
T |  11   0   9  24  67  96
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------TGKG----YCFA--------------   L                        +--------4pxi_B    
                                                 +------------2 
  ------TTRG----YTWA--------------   L           !            +--------7jnp_A    
                                               +-4 
  --VT--AGDT--TTYTLA--------------   L         ! !                    +5gpc_B    
                                               ! !    +---------------1 
  --LC--RTPTPTSTYT----------------   L      +--5 +----3               +6nsn_B    
                                            !  !      ! 
  ------TCKGAG--YTHA--------------          !  !      +----------------5k7z_A    
                                         +--6  ! 
  --MTRGTGPT--ATYTWT--------------   L   !  !  +----------------------5yej_B    
                                       --7  ! 
  RG----HCRG--------RGQAQGKG------   L   !  +-------------------------2glo_A    
                                         ! 
  ----------------------NT--NAITRG       +----------------------------5zjt_B    
                                       

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updated Fri Sep 13 18:39:19 2024