interface graph thumbnail
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structure nameWILMS TUMOR PROTEIN (WT1) ZINC FINGERS IN COMPLEX WITH FORMYLATED DNA
(Wilms tumor protein, isoform 4CRA_a)
referenceOlanrewaju et al. 'Genes 28 2304 2014
sourceHomo sapiens
experimentX-ray (resolution=1.54, R-factor=0.162)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
redundant complexes4r2s 4r2r 4r2e 4r2p
reference complex5kl3_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRDQRRSDHTRDER

Estimated binding specificities ?

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# IC=7.347 IC/col=0.816 n_of_columns=9 specificity:   
A |   9   0   8   0   3   2   0  10  16
C |   9  96   8   0   5   2   0  13  16
G |  67   0  72   0  85  88  96  63  16
T |  11   0   8  96   3   4   0  10  48
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----RGSTDAQG--RG--RG--DCHG--TTRG--DAEC--RG--   L                                   +4r2q_A    
                                                                              +------1 
  ----RA----NC--------ATSGDC--KGDCPTSGSARTKG--   L                          +-6      +2gli_A    
                                                                            ! ! 
  PCYCRG--DA----RG--RG--DCHG----RG--DCEC--RG--   L                    +-----7 +------2prt_A    
                                                                      !     ! 
  ----QA--SGNA--KG--QASTSCDC--KGRG--DCHA--RG--   L                +---9     +-------1mey_C    
                                                                  !   ! 
  ----RG--DCEC--RG--RG--DCHG------------------   L                !   !      +------1f2i_J    
                                                                  !   +------5 
  ----------------RGST--YGYC----QC--TGSTRGYT--   L                !          +------4is1_C    
                                                                  !  
  ----EC--SCKG--RG--LT--FCNA----QA--TTNA------   L             +-11                 +1ubd_C    
                                                               !  !      +----------3 
  ----DA--SCHG--RGRGDC--SCNA----NCKTSAHG--RG--   L             !  !      !          +5ei9_F    
                                                               !  !  +---8 
  ----RGSTDTEG--RG--RGSGDCHG--TTRG--DAEG--RG--   L             !  !  !   !          +4x9j_A    
                                                           +--12  +-10   +----------2 
  --------KGDC--RG--QARGATNA----QA--ATHG------   L         !   !     !              +2i13_A    
                                                           !   !     !  
  ----QA--TCNA------QAHTTT----QATTLAHGTCDTRG--   L         !   !     +--------------1g2d_F    
                                                        +-13   !  
  ----QA--TTNA----STQAQTATSTNTATTTLAHGTC--RG--   L      !  !   !                  +-1g2f_F    
                                                        !  !   +------------------4 
  --------TTSG--RG--LT--ETYC----NTYGQG--------   L   +-14  !                      +-4f6m_A    
                                                     !  !  !  
  ----KG--WTKA----------HCHG--RGTA--ACNA--KGRG   L   !  !  +------------------------1tf6_A    
                                                   -15  !  
  ----HTITSTNACTRG--RG--DCNA------------------   L   !  +-------------------------2drp_D    
                                                     !  
  ------------------RG--DGEC--RGRGSGDCHA------   L   +--------------------------2wbs_A    
                                                   

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updated Thu Sep 12 20:01:55 2024