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structure nameWILMS TUMOR PROTEIN (WT1) ZNF2-4 Q369H IN COMPLEX WITH DNA
(Wilms tumor protein)
referenceHashimoto et al. 'Nucleic 44 10165 2016
sourceHomo sapiens
experimentX-ray (resolution=1.45, R-factor=0.163)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
redundant complexes4r2e_A 4r2p_A 4r2q_A 4r2r_A 4r2s_A 5kl2_A 5kl4_D 5kl5_A 5kl6_A 5kl7_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRDHRRSDHTRDER

Estimated binding specificities ?

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# IC=11.003 IC/col=1.100 n_of_columns=10 specificity:   
A |   0   0   0   1  14   0   0  83   0  13
C |   0  96   0  13   0   0   0   0   0  13
G |  96   0  96   0  82  96  96  13  96  54
T |   0   0   0  82   0   0   0   0   0  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --KG--WTKA--------HCHGRG--TAACNA--KGRG   L                               +1tf6_A    
                                                               +-----------1 
  NGKT--WTKG--------HTHGRGTGTTACNA--KGRG   L   +---------------3           +1tf3_A    
                                               !               ! 
  ------------RGST--YGYC----QCTGSTRGYT--       !               +-----------4is1_C    
                                               ! 
  --CT--STQTLTITST--STHTRG--RG--EA--RA--   L   !        +-------------------5v3j_F    
                                               !        ! 
  --VT----NARG------ETTG----YGST--------     --8   +----5                +--6e94_A    
                                               !   !    !   +------------2 
  --DG--YCKGRG--QA----TC----RASCDC--VT--   L   !   !    +---4            +--5k5h_A    
                                               ! +-6        ! 
  --------------QA----TCRG--RGYCRT------   L   ! ! !        +---------------7txc_E    
                                               +-7 ! 
  --NT--STNAVT--QTSTSGKGRG--------------   L     ! +------------------------6u9q_A    
                                                 ! 
  QT--AG--KGRG--RG--DCKG----------------   L     +-------------------------7n5w_A    
                                             

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updated Fri Sep 13 19:59:11 2024