4uzb_B : 3D-footprint complex

structure name	KSHV LANA (ORF73) C-TERMINAL DOMAIN MUTANT BOUND TO LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D) (ORF 73)
reference	Hellert et al.
source	HUMAN HERPESVIRUS 8
experiment	X-ray (resolution=2.87, R-factor=0.123)
structural superfamily	Viral DNA-binding domain;
multimeric complexes	4uzb_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4uzb_B interface=2,3,4,5,21, pHPRYqqppvpyrqiddcpaKarpqhifyqqflgkdgrrdpkcqwefavifwgndpyglkklsqafqfggvkagpvsclphpgpdqspitycvyvycqnaatskkvqmarleweashplagnlqssivsfddplplt
interface signature	HPRYK

Estimated binding specificities ?

readout + contact

# IC=6.272 IC/col=0.523 n_of_columns=12

specificity:

A |   0  17  24  24  24  24  24   8   0   0   0   8
C |  96  45  24  24  24  24  24  61  96  96   0  11
G |   0  17  24  24  24  24  24   8   0   0  96  69
T |   0  17  24  24  24  24  24  19   0   0   0   8

scan!

Dendrogram of similar interfaces ?

matrix format

  
  HGPCRG--KG----------------------------------   L                 +-----4uzb_B    
                                                     +-------------1 
  ------NTKGFTKTTGYCNGRT----------------------   L   !             +-----1b3t_A    
                                                   --3 
  ----------------------LAKATGTGSGVGFA--RAECTA   L   !         +---------5tkz_B    
                                                     +---------2 
  ------------------------------------LG------                 +---------6dgd_B

home
updated Sun Aug 3 08:31:55 2025