4uzb_B : 3D-footprint complex

structure name	KSHV LANA (ORF73) C-TERMINAL DOMAIN MUTANT BOUND TO LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D) (ORF 73)
reference	Hellert et al.
source	HUMAN HERPESVIRUS 8
experiment	X-ray (resolution=2.87, R-factor=0.123)
structural superfamily	Viral DNA-binding domain;
multimeric complexes	4uzb_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4uzb_B interface=2,3,4,5,21, pHPRYqqppvpyrqiddcpaKarpqhifyqqflgkdgrrdpkcqwefavifwgndpyglkklsqafqfggvkagpvsclphpgpdqspitycvyvycqnaatskkvqmarleweashplagnlqssivsfddplplt
interface signature	HPRYK

Estimated binding specificities ?

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# IC=5.564 IC/col=0.506 n_of_columns=11

specificity:

A |   0   0   0  24  24  24  24  24  24  12   0
C |  96   0   0  12  24  24  24  24  24  24   0
G |   0  96  96  48  24  24  24  24  24  36  96
T |   0   0   0  12  24  24  24  24  24  24   0

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Dendrogram of similar interfaces ?

matrix format

  
  HGPCRG--KG----------------------------------   L                 +-----4uzb_B    
                                                     +-------------1 
  ------NTKGFTKTTGYCNGRT----------------------   L   !             +-----1b3t_A    
                                                   --3 
  ----------------------LAKATGTGSGVGFA--RAECTA   L   !         +---------5tkz_B    
                                                     +---------2 
  ------------------------------------LG------                 +---------6dgd_B

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updated Fri Sep 13 18:49:33 2024