4y0f_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HUMAN TDP-43 RRM1 DOMAIN IN COMPLEX WITH AN UNMODIFIED SINGLE-STRANDED DNA (TAR DNA-binding protein 43)
reference	Doudeva et al. 'Sci 6 21581 2016
source	Homo sapiens
experiment	X-ray (resolution=2.65, R-factor=0.245)
structural superfamily	RNA-binding domain, RBD;
sequence family	RNA recognition motif aka RRM, RBD, or;
redundant complexes	4y00_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4y0f_A interface=3,5,7,11,32,34,37,43,45,47,69,76,77,78, tsDlIvLglpWktteqdlkeyfstfgevlmvQvKkdLktghsKgFgFvrfteyetqvkvmsqrhmidgRwcdcklPNS
interface signature	DILWQKLKFFRPNS

Estimated binding specificities ?

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# IC=8.431 IC/col=1.054 n_of_columns=8

specificity:

A |   0   0  54   0   0   0   0  16
C |   0   0  13   0  96   0   0  13
G |   0  96  16  96   0  96   0  13
T |  96   0  13   0   0   0  96  54

scan!

Dendrogram of similar interfaces ?

matrix format

  
  DGICLGWG--QGKT--LT--KGFGFGRG----PCNC   L                     +----4y0f_A    
                                             +-----------------2 
  TAFCSG----LAKATG--TGSGVGFA--RAECACKC   L   !                 ! +--5tkz_B    
                                           --3                 +-1 
  TAFCAG----RC------------FA--RAEGACRC   L   !                   +--6dg0_A    
                                             ! 
  --------RA--------------------------   L   +----------------------6mrj_D

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updated Fri Sep 13 19:01:24 2024