| structure name | CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA (ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1) |
| reference | Rastinejad et al. Nature 524 303 2015 |
| source | MUS MUSCULUS |
| experiment | X-ray (resolution=3.60, R-factor=0.238) |
| structural superfamily | PYP-like sensor domain PAS domain;HLH, helix-loop-helix DNA-binding domain; |
| sequence family | PAS fold; Helixloophelix DNAbinding domain; |
| multimeric complexes | 4zpk_AB |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: ARNT | ||
| CACGTG | PubMed | 4zpk_AB(6.26e-06) |
| GCGTG | PubMed | 4zpk_AB(1.01e-03) |
| CACGC | PubMed | 4zpk_AB(1.01e-03) |
| CACGCN | PubMed | 4zpk_AB(3.38e-03) |
| AACGTG | PubMed | 4zpk_AB(6.26e-06) |
| GTGCGTG | PubMed | 4zpk_AB(5.20e-05) |
| TNGCGTG | PubMed | 4zpk_AB(1.04e-02) |
| TTGCGTG | PubMed | 4zpk_AB(1.04e-02) |
Dendrogram of similar interfaces ?
matrix format--RT------NTRGEC--RCQT +2ypa_A +--1 KT------HGNT--EC--RCRG L ! +1nkp_A +---3 --------HGNT--EC--RCRG L ! ! +-1nkp_E +-------4 +-2 --------HGNTMTEA--RCRG L ! ! +-1nlw_D --5 ! --HGST--ITET--RCRG---- L ! +-------4h10_A ! --NT--RAEC--RC-------- +---------------2ypa_B |
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updated Fri Sep 13 19:06:10 2024