| structure name | CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-1A:ARNT COMPLEX WITH HRE DNA (HYPOXIA-INDUCIBLE FACTOR 1-ALPHA) |
| reference | Rastinejad et al. Nature 524 303 2015 |
| source | MUS MUSCULUS |
| experiment | X-ray (resolution=3.90, R-factor=0.272) |
| structural superfamily | PYP-like sensor domain PAS domain;HLH, helix-loop-helix DNA-binding domain; |
| sequence family | PAS fold; |
| multimeric complexes | 4zpr_AB |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: ARNT | ||
| CACGTG | PubMed | 4zpr_AB(1.12e-03) |
| GCGTG | PubMed | 4zpr_AB(3.54e-04) |
| AACGTG | PubMed | 4zpr_AB(1.12e-03) |
| TNGCGTG | PubMed | 4zpr_AB(3.37e-03) |
| CACGC | PubMed | 4zpr_AB(3.54e-04) |
| CACGCN | PubMed | 4zpr_AB(1.12e-03) |
| GTGCGTG | PubMed | 4zpr_AB(3.37e-03) |
| TTGCGTG | PubMed | 4zpr_AB(3.37e-03) |
| CCACGTGG | PubMed | 4zpr_AB(6.34e-03) |
| TCACGTGA | PubMed | 4zpr_AB(6.34e-03) |
Dendrogram of similar interfaces ?
matrix format----ST----ATRTRG +4zpk_B +---1 RT----NTRGECRCQT +-2 +2ypa_A ! ! NTRAEC--RC------ --3 +---2ypa_B ! ----HGSTITETRCRG L +----4h10_A |
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updated Sun Aug 3 08:45:51 2025