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structure nameCRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-1A:ARNT COMPLEX WITH HRE DNA
(HYPOXIA-INDUCIBLE FACTOR 1-ALPHA)
referenceRastinejad et al. Nature 524 303 2015
sourceMUS MUSCULUS
experimentX-ray (resolution=3.90, R-factor=0.272)
structural superfamilyPYP-like sensor domain PAS domain;HLH, helix-loop-helix DNA-binding domain;
sequence familyPAS fold;
multimeric complexes4zpr_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence

No structural evidence for specific binding to DNA (<4 informative columns)


Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ARNT
CACGTGPubMed4zpr_AB(1.12e-03)
GCGTGPubMed4zpr_AB(3.54e-04)
AACGTGPubMed4zpr_AB(1.12e-03)
TNGCGTGPubMed4zpr_AB(3.37e-03)
CACGCPubMed4zpr_AB(3.54e-04)
CACGCNPubMed4zpr_AB(1.12e-03)
GTGCGTGPubMed4zpr_AB(3.37e-03)
TTGCGTGPubMed4zpr_AB(3.37e-03)
CCACGTGGPubMed4zpr_AB(6.34e-03)
TCACGTGAPubMed4zpr_AB(6.34e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----ST----ATRTRG             +4zpk_B    
                           +---1 
  RT----NTRGECRCQT       +-2   +2ypa_A    
                         ! ! 
  NTRAEC--RC------     --3 +---2ypa_B    
                         ! 
  ----HGSTITETRCRG   L   +----4h10_A    
                       

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updated Fri Sep 13 19:06:21 2024