5axw_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA (TTGGGT PAM) (CRISPR-associated endonuclease Cas9)
reference	Nishimasu et al. Cell 162 1113 2015
source	Staphylococcus aureus subsp. aureus
experiment	X-ray (resolution=2.70, R-factor=0.205)
structural superfamily	Ribonuclease H-like;
multimeric complexes	8jg9_ACF
reference complex	7vw3_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5axw_A interface=976,977,980,982,993,1004,1006, rnyilgldigitsvgygiidyetrdvidagvrlfkeanvennegrrskrgarrlkrrrrhriqrvkkllfdynlltdhselsginpyearvkglsqklseeefsaallhlakrrgvhnvneveedtgnelstkeqisrnskaleekyvaelqlerlkkdgevrgsinrfktsdyvkeakqllkvqkayhqldqsfidtyidlletrrtyyegpgegspfgwkdikewyemlmghctyfpeelrsvkyaynadlynalndlnnlvitrdenekleyyekfqiienvfkqkkkptlkqiakeilvneedikgyrvtstgkpeftnlkvyhdikditarkeiienaelldqiakiltiyqssediqeeltnlnseltqeeieqisnlkgytgthnlslkainlildelwhtndnqiaifnrlklvpkkvdlsqqkeipttlvddfilspvvkrsfiqsikvinaiikkyglpndiiielareknskdaqkminemqkrnrqtnerieeiirttgkenakyliekiklhdmqegkclysleaipledllnnpfnyevdhiiprsvsfdnsfnnkvlvkqeeaskkgnrtpfqylsssdskisyetfkkhilnlakgkgrisktkkeylleerdinrfsvqkdfinrnlvdtryatrglmnllrsyfrvnnldvkvksinggftsflrrkwkfkkernkgykhhaedaliianadfifkewkkldkakkvmenqmfmpeieteqeykeifitphqikhikdfkdykyshrvdkkpnrelindtlystrkddkgntlivnnlnglydkdndklkklinkspekllmyhhdpqtyqklklimeqygdeknplykyyeetgnyltkyskkdngpvikkikyygnklnahlditddypnsrnkvvklslkpyrfdvyldngvykfvtvknldvikkenyyevnskayeeakklkkisnqaefiasfynndlikingelyrvigvNNdlLnRievnmidityReylenmndkrPpRiiktiasktqsikkystdilgnlyevkskkhpqiikk
interface signature	NNLRRPR

Estimated binding specificities ?

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# IC=4.250 IC/col=0.850 n_of_columns=5

specificity:

A |  96  12   0   0  60
C |   0  60  84  96  12
G |   0  12   0   0  12
T |   0  12  12   0  12

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updated Tue Dec 17 00:54:14 2024