interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA (TTGGGT PAM)
(CRISPR-associated endonuclease Cas9)
referenceNishimasu et al. Cell 162 1113 2015
sourceStaphylococcus aureus subsp. aureus
experimentX-ray (resolution=2.70, R-factor=0.205)
structural superfamilyRibonuclease H-like;
multimeric complexes8jg9_ACF
reference complex7vw3_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNNLRRPR

Estimated binding specificities ?

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# IC=4.046 IC/col=0.809 n_of_columns=5 specificity:   
A |   9   0   9   9   0
C |  11   0   9   9   0
G |   9  96  69  69   0
T |  67   0   9   9  96
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updated Fri Jan 9 02:23:45 2026