5c8e_BC : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARH BOUND TO ADENOSYLCOBALAMIN AND A 26-BP DNA SEGMENT
reference	Drennan et al. Nature 526 536 2015
source	Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experiment	X-ray (resolution=3.89, R-factor=?)
structural superfamily	Putative DNA-binding domain;Cobalamin vitamin B12-binding domain;
reference complex	5c8e_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5c8e_B interface=18,21,25, gvytiaeveamtglsaeVlrQwerRygfpkprrtpgghrlysaedvealktikrwleegatpkaairrylaqevrpedlgtglleallrgdlagaealfrrglrfwgpegvlehlllpvlrevgeawhrgeigvaeehlastflrarlqelldlagfppgppvlvttppgerheigamlaayhlrrkgvpalylgpdtplpdlralarrlgagavvlsavlseplralpdgalkdlaprvflggqgagpeearrlgaeymedlkglaealwlprgp > 5c8e_C interface=22,25,26,29,30,43, hmtssgvytiaeveamtglsaEvlRQweRRygfpkprrtpggHrlysaedvealktikrwleegatpkaairrylaqevrpedlgtglleallrgdlagaealfrrglrfwgpegvlehlllpvlrevgeawhrgeigvaeehlastflrarlqelldlagfppgppvlvttppgerheigamlaayhlrrkgvpalylgpdtplpdlralarrlgagavvlsavlseplralpdgalkdlaprvflggqgagpeearrlgaeymedlkglaealwlpr
interface signature	VQR/ERQRRH

Estimated binding specificities ?

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# IC=8.542 IC/col=0.569 n_of_columns=15

specificity:

A |   5  96   0  79  24  24  24  24  24  24  11   0  96   5  84
C |   5   0  96   5  24  24  24  24  24  24   7   0   0  67   0
G |   7   0   0   5  24  24  24  24  24  24  11  96   0  13   5
T |  79   0   0   7  24  24  24  24  24  24  67   0   0  11   7

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updated Wed Jul 30 06:22:47 2025