5c8e_BC : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARH BOUND TO ADENOSYLCOBALAMIN AND A 26-BP DNA SEGMENT
reference	Drennan et al. Nature 526 536 2015
source	Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experiment	X-ray (resolution=3.89, R-factor=?)
structural superfamily	Putative DNA-binding domain;Cobalamin vitamin B12-binding domain;
reference complex	5c8e_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5c8e_B interface=18,21,25, gvytiaeveamtglsaeVlrQwerRygfpkprrtpgghrlysaedvealktikrwleegatpkaairrylaqevrpedlgtglleallrgdlagaealfrrglrfwgpegvlehlllpvlrevgeawhrgeigvaeehlastflrarlqelldlagfppgppvlvttppgerheigamlaayhlrrkgvpalylgpdtplpdlralarrlgagavvlsavlseplralpdgalkdlaprvflggqgagpeearrlgaeymedlkglaealwlprgp > 5c8e_C interface=22,25,26,29,30,43, hmtssgvytiaeveamtglsaEvlRQweRRygfpkprrtpggHrlysaedvealktikrwleegatpkaairrylaqevrpedlgtglleallrgdlagaealfrrglrfwgpegvlehlllpvlrevgeawhrgeigvaeehlastflrarlqelldlagfppgppvlvttppgerheigamlaayhlrrkgvpalylgpdtplpdlralarrlgagavvlsavlseplralpdgalkdlaprvflggqgagpeearrlgaeymedlkglaealwlpr
interface signature	VQR/ERQRRH

Estimated binding specificities ?

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# IC=9.545 IC/col=0.636 n_of_columns=15

specificity:

A |   0  12   0   0  64  24  24  24  24  12  24   0   0   0  85
C |   0  10   0  96  10  24  24  24  24  16  24   5   0   0   6
G |   0  64   0   0  10  24  24  24  24  10  24   6  96   0   5
T |  96  10  96   0  12  24  24  24  24  58  24  85   0  96   0

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updated Mon Jan 5 15:09:06 2026