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legend  pdf

structure nameCRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARH BOUND TO ADENOSYLCOBALAMIN AND A 26-BP DNA SEGMENT
(Light-dependent transcriptional regulator CarH)
referenceDrennan et al. Nature 526 536 2015
sourceThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experimentX-ray (resolution=3.89, R-factor=0.251)
structural superfamilyPutative DNA-binding domain;Cobalamin vitamin B12-binding domain;
sequence familyMerR family regulatory protein;
multimeric complexes5c8e_AF 5c8e_BC 5c8e_EG
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureERQRRH

Estimated binding specificities ?

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# IC=3.727 IC/col=0.745 n_of_columns=5 specificity:   
A |  26   0  96   8  69
C |   0   0   0  52   8
G |  18  96   0  19   8
T |  52   0   0  17  11
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: CARH
TACANPubMed5c8e_AF(1.01e-03), 5c8e_BC(1.24e-02)

Dendrogram of similar interfaces ?

matrix format
  
  RGRTYTKT----------   L                                 +7tea_B    
                                                      +--1 
  RGHTHCYG----------   L                   +----------2  +1r8d_B    
                                           !          ! 
  RCRT--------------       +---------------3          +--7tec_A    
                           !               ! 
  RART--------------     --4               +-------------4r24_B    
                           ! 
  --------RGEGSGKGKG       +-----------------------------1m5r_B

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updated Fri Sep 13 19:23:28 2024