5e69_AB : 3D-footprint complex

structure name	GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL8 NF-KB RESPONSE ELEMENT COMPLEX
reference	Ortlund et al. 'Nat 9 1337 2018
source	Homo sapiens
experiment	X-ray (resolution=1.85, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5e69_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5e69_A interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea > 5e69_B interface=26,30, pklclvcsdeasgchygvltcgsckVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea
interface signature	KVR/VR

Estimated binding specificities ?

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# IC=5.157 IC/col=0.516 n_of_columns=10

specificity:

A |   0   5  24  24  24  96  96  25  24   6
C |  96  26  24  24  24   0   0  21  24   0
G |   0  45  24  24  24   0   0  15  24   5
T |   0  20  24  24  24   0   0  35  24  85

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updated Wed Jul 30 07:15:03 2025