5e69_AB : 3D-footprint complex

structure name	GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL8 NF-KB RESPONSE ELEMENT COMPLEX
reference	Ortlund et al. 'Nat 9 1337 2018
source	Homo sapiens
experiment	X-ray (resolution=1.85, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	3g9m_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5e69_A interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea > 5e69_B interface=26,30, pklclvcsdeasgchygvltcgsckVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea
interface signature	KVR/VR

Estimated binding specificities ?

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# IC=4.990 IC/col=0.499 n_of_columns=10

specificity:

A |   0  14  24  24  24  96  73   7  24   7
C |  96  16  24  24  24   0   9   7  24   7
G |   0  66  24  24  24   0   7  16  24   1
T |   0   0  24  24  24   0   7  66  24  81

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updated Mon Jan 5 16:09:03 2026