5e69_AB : 3D-footprint complex

structure name	GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL8 NF-KB RESPONSE ELEMENT COMPLEX
reference	Ortlund et al. 'Nat 9 1337 2018
source	Homo sapiens
experiment	X-ray (resolution=1.85, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5e69_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5e69_A interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea > 5e69_B interface=26,30, pklclvcsdeasgchygvltcgsckVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea
interface signature	KVR/VR

Estimated binding specificities ?

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# IC=5.326 IC/col=0.533 n_of_columns=10

specificity:

A |  67  24  68   0   0  24  24  24   9   0
C |   9  24   9   0   0  24  24  24  59   0
G |   9  24  19   0   0  24  24  24  19  96
T |  11  24   0  96  96  24  24  24   9   0

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updated Tue Sep 10 03:43:44 2024