5e6a_AB : 3D-footprint complex

structure name	GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - PLAU NF-KB RESPONSE ELEMENT COMPLEX
reference	Ortlund et al. 'Nat 9 1337 2018
source	Homo sapiens
experiment	X-ray (resolution=2.20, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	5e69_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5e6a_A interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea > 5e6a_B interface=30, pklclvcsdeasgchygvltcgsckvffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlea
interface signature	KVR/R

Estimated binding specificities ?

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# IC=5.105 IC/col=0.510 n_of_columns=10

specificity:

A |  11  24  69   8   0  24  24  24   0   0
C |   8  24   8  11   8  24  24  24   0   0
G |  69  24  11   8   1  24  24  24   0  96
T |   8  24   8  69  87  24  24  24  96   0

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updated Wed Jul 30 07:15:11 2025