5f8a_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE TERNARY ECORV-DNA-LU COMPLEX WITH UNCLEAVED DNA SUBSTRATE. LANTHANIDE BINDING TO ECORV-DNA COMPLEX INHIBITS CLEAVAGE.
reference	Jen-Jacobson et al. Biochemistry 55 6115 2016
source	Escherichia coli
experiment	X-ray (resolution=1.76, R-factor=?)
structural superfamily	Restriction endonuclease-like;
reference complex	1eon_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5f8a_A interface=37,69,103,105,179,182,184,185,187, slrsdlinalydenqkydvcgiisaegkiyplgsdtKvlstifelfsrpiinkiaekhgyiveepkqqNhypdftlykpsepnkkiaidikttytnkenekiKfTlggytsfirnntknivypfdqyiahwiigyvytrvatrksslktyninelneipkpykgvkvflqdkwviagdLagSgNTtNigsihahykdfvegkgifdsedefldywrnyertsqlrndkynniseyrnwiyrgrk > 5f8a_B interface=37,69,105,182,184,185,187, slrsdlinalydenqkydvcgiisaegkiyplgsdtKvlstifelfsrpiinkiaekhgyiveepkqqNhypdftlykpsepnkkiaidikttytnkenekikfTlggytsfirnntknivypfdqyiahwiigyvytrvatrksslktyninelneipkpykgvkvflqdkwviagdlagSgNTtNigsihahykdfvegkgifdsedefldywrnyertsqlrndkynniseyrnwiyrgrk
interface signature	KNKTLSNTN/KNTSNTN

Estimated binding specificities ?

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# IC=5.460 IC/col=0.607 n_of_columns=9

specificity:

A |  12  95   4  90   0  12  21  16  54
C |  12   0   3   1   0  60  22  25  12
G |  60   1   4   1   0  12  18  25  13
T |  12   0  85   4  96  12  35  30  17

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updated Wed Jul 30 07:19:40 2025