1eon_A : 3D-footprint complex

structure name	ECORV BOUND TO 3'-S-PHOSPHOROTHIOLATE DNA AND CA2+ (TYPE II RESTRICTION ENZYME ECORV)
reference	Connolly et al. J.Am.Chem.Soc. 122 3314 2000
source	Escherichia coli
experiment	X-ray (resolution=1.60, R-factor=0.230)
structural superfamily	Restriction endonuclease-like;
sequence family	Restriction endonuclease EcoRV;
multimeric complexes	1az0_AB 1b94_AB 1b95_AB 1b96_AB 1b97_AB 1bgb_AB 1bss_AB 1bsu_AB 1bua_AB 1eo3_AB 1eo4_AB 1eon_AB 1eoo_AB 1eop_AB 1rv5_AB 1rva_AB 1rvb_AB 1suz_AB 1sx8_AB 2b0d_AB 2b0e_AB 2ge5_AB 4rve_AB 5f8a_AB
redundant complexes	1az0_A 1b94_A 1b95_B 1b96_A 1b97_B 1bgb_A 1bss_B 1bsu_B 1bua_A 1eo3_B 1eo4_B 1eoo_A 1eop_A 1rv5_A 1rva_B 1rvb_A 1suz_A 1sx8_A 2b0d_B 2b0e_B 2ge5_A 4rve_C 5f8a_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1eon_A interface=69,105,174,176,177,179, slrsdlinalydenqkydvcgiisaegkiyplgsdtkvlstifelfsrpiinkiaekhgyiveepkqqNhypdftlykpsepnkkiaidikttytnkenekikfTlggytsfirnntknivypfdqyiahwiigyvytrvksslktyniipkpykgvkvflqdkwviagdlagSgNTtNigsihahykdfvegkgifdsedefldywrnyertsqlrndkynniseyrnwiyrgrk
interface signature	NTSNTN

Estimated binding specificities ?

readout + contact

# IC=3.184 IC/col=0.531 n_of_columns=6

specificity:

A |   0  96  24  24  13  13
C |   0   0  24  24  13  57
G |  96   0  24  24  13  13
T |   0   0  24  24  57  13

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ------NC------TT--SGNATTNT   L                             +--1eon_A    
                                        +--------------------1 
  ------NC------TT--STNATTNT   L     +--2                    +--2ge5_B    
                                     !  ! 
  ----QANT----PANA--YGNG----   L   +-3  +-----------------------2gig_A    
                                   ! ! 
  TAKT------TT----DC--------   L --4 +--------------------------2ost_A    
                                   ! 
  --------DC----------------   L   +---------------------------1dmu_A

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updated Sun Aug 3 05:28:44 2025